tilingArray

Transcript mapping with high-density oligonucleotide tiling arrays

The package provides functionality that can be useful for the analysis of high-density tiling microarray data (such as from Affymetrix genechips) for measuring transcript abundance and architecture. The main functionalities of the package are: 1. the class 'segmentation' for representing partitionings of a linear series of data; 2. the function 'segment' for fitting piecewise constant models using a dynamic programming algorithm that is both fast and exact; 3. the function 'confint' for calculating confidence intervals using the strucchange package; 4. the function 'plotAlongChrom' for generating pretty plots; 5. the function 'normalizeByReference' for probe-sequence dependent response adjustment from a (set of) reference hybridizations.

Author Wolfgang Huber, Zhenyu Xu, Joern Toedling with contributions from Matt Ritchie
Maintainer Zhenyu Xu

To install this package, start R and enter:

    source("http://bioconductor.org/biocLite.R")
    biocLite("tilingArray")

Documentation

Normalisation with the normalizeByReference function in the tilingArray package PDF R Script
Supplement. Calculation of the cost matrix PDF R Script
Introduction to using the segment function to fit a piecewise constant curve PDF R Script
Segmentation demo PDF R Script
Reference Manual

Details

biocViews
Depends
Biobase , methods , pixmap
Imports
strucchange , affy , vsn , genefilter , RColorBrewer , grid
Suggests
System Requirements
License The Artistic License, Version 2.0
URL
Depends On Me
Imports Me
Suggests Me
Development History Bioconductor Changelog

Package Downloads

Package source tilingArray_1.22.0.tar.gz
Windows binary tilingArray_1.22.0.zip
MacOS X 10.4 (Tiger) binary tilingArray_1.22.0.tgz
MacOS X 10.5 (Leopard) binary tilingArray_1.22.0.tgz
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