Estimate a Gaussian distribution for the null Z-scores.
The observed Z-scores consist of both null and non-null values. The fitted distribution of null Z-scores is Gaussian, but may have non-zero mean and/or non-unit scale.
Parameters: | zscores : array-like
null_lb : float
null_ub : float
estimate_mean : bool
estimate_scale : bool
estimate_null_proportion : bool
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Notes
See also:
References
B Efron (2008). Microarrays, Empirical Bayes, and the Two-Groups Model. Statistical Science 23:1, 1-22.
Attributes
mean | float | The estimated mean of the empirical null distribution |
sd | float | The estimated standard deviation of the empirical null distribution |
null_proportion | float | The estimated proportion of true null hypotheses among all hypotheses |
Methods
pdf(zscores) | Evaluates the fitted emirical null Z-score density. |
Methods
pdf(zscores) | Evaluates the fitted emirical null Z-score density. |